USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P10619 USC-OGP 2-DE database:  P10619 P10619 General information about the entry View entry in simple text format Entry name PPGB_HUMAN Primary accession number P10619 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Lysosomal protective protein; EC=3.4.16.5; AltName: Full=Carboxypeptidase C; AltName: Full=Carboxypeptidase L; AltName: Full=Cathepsin A; AltName: Full=Protective protein cathepsin A; Short=PPCA; AltName: Full=Protective protein for beta-galactosidase; Contains: RecName: Full=Lysosomal protective protein 32 kDa chain; Contains: RecName: Full=Lysosomal protective protein 20 kDa chain; Flags: Precursor;. Gene name Name=CTSA Synonyms=PPGB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-5 {PLATELET 4-5} Homo sapiens (Human)   map experimental info   PLATELET_4-5 MAP LOCATIONS: SPOT OGP-0160: pI=4.57; Mw=29717 SPOT OGP-0162: pI=4.63; Mw=29303 SPOT OGP-0163: pI=4.68; Mw=28692 Cross-references UniProtKB/Swiss-Prot P10619; PPGB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PPGB_HUMAN Primary accession number P10619 Secondary accession number(s) B2R798 Q561W6 Q5JZH1 Q96KJ2 Q9BR08 Q9BW68 Sequence was last modified on  April 16, 2002 (version 2) Annotations were last modified on  March 15, 2017 (version 206) Name and origin of the protein Description RecName: Full=Lysosomal protective protein; EC=3.4.16.5; AltName: Full=Carboxypeptidase C; AltName: Full=Carboxypeptidase L; AltName: Full=Cathepsin A; AltName: Full=Protective protein cathepsin A; Short=PPCA; AltName: Full=Protective protein for beta-galactosidase; Contains: RecName: Full=Lysosomal protective protein 32 kDa chain; Contains: RecName: Full=Lysosomal protective protein 20 kDa chain; Flags: Precursor; Gene name Name=CTSA Synonyms=PPGB Encoded on Name=CTSA; Synonyms=PPGB Keywords 3D-structure; Alternative splicing; Carboxypeptidase; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hydrolase; Lysosome; Protease; Reference proteome; Signal; Zymogen. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M22960; AAA36476.1; -; mRNA EMBL AK312898; BAG35745.1; -; mRNA EMBL AL008726; CAA15501.1; -; Genomic_DNA EMBL AL008726; CAI20248.1; ALT_INIT; Genomic_DNA EMBL BC000597; AAH00597.1; -; mRNA EMBL BC093009; AAH93009.1; -; mRNA CCDS CCDS46609.1; -. [P10619-1]; . PIR A31589; A31589; . RefSeq NP_000299.2; NM_000308.3; . RefSeq NP_001121167.1; NM_001127695.2. [P10619-1]; . RefSeq NP_001161066.1; NM_001167594.2; . UniGene Hs.609336; -; . PDB 1IVY; X-ray; 2.20 A; A/B=29-480 PDB 3BP4; X-ray; 1.85 A; C=2-10 PDB 3BP7; X-ray; 1.80 A; C=2-10 PDB 3BXN; X-ray; 1.86 A; C=2-10 PDB 4AZ0; X-ray; 2.17 A; A=29-326 B=327-480 PDB; 4AZ3; X-ray; 2.04 A A=29-326 B=327-480; PDB; 4CI9; X-ray 1.58 A A=29-480; PDB; 4CIA; X-ray 1.98 A A=29-480; PDB; 4CIB; X-ray 1.89 A A=29-480; PDB; 4MWS; X-ray 2.80 A A/B=29-480; PDB; 4MWT; X-ray 3.85 A A/B=29-480; PDBsum; 1IVY; - PDBsum 3BP4; -; . PDBsum 3BP7; -; . PDBsum 3BXN; -; . PDBsum 4AZ0; -; . PDBsum 4AZ3; -; . PDBsum 4CI9; -; . PDBsum 4CIA; -; . PDBsum 4CIB; -; . PDBsum 4MWS; -; . PDBsum 4MWT; -; . ProteinModelPortal P10619; -; . SMR P10619; -; . BioGrid 111472; 33; . IntAct P10619; 12; . MINT MINT-3007366; -; . STRING 9606.ENSP00000361562; -; . BindingDB P10619; -; . ChEMBL CHEMBL6115; -; . GuidetoPHARMACOLOGY 1581; -; . ESTHER human-CTSA; Carboxypeptidase_S10; . MEROPS S10.002; -; . iPTMnet P10619; -; . PhosphoSitePlus P10619; -; . SwissPalm P10619; -; . BioMuta CTSA; -; . DMDM 20178316; -; . OGP P10619; -; . EPD P10619; -; . MaxQB P10619; -; . PaxDb P10619; -; . PeptideAtlas P10619; -; . PRIDE P10619; -; . TopDownProteomics P10619-1; -. [P10619-1]; . TopDownProteomics P10619-2; -. [P10619-2]; . DNASU 5476; -; . Ensembl ENST00000191018; ENSP00000191018; ENSG00000064601. [P10619-1]; . Ensembl ENST00000372459; ENSP00000361537; ENSG00000064601. [P10619-1]; . GeneID 5476; -; . KEGG hsa:5476; -; . UCSC uc002xqj.5; human. [P10619-1]; . CTD 5476; -; . DisGeNET 5476; -; . GeneCards CTSA; -; . HGNC HGNC:9251; CTSA; . HPA CAB024930; -; . HPA HPA031068; -; . MalaCards CTSA; -; . MIM 256540; phenotype; . MIM 613111; gene; . neXtProt NX_P10619; -; . OpenTargets ENSG00000064601; -; . Orphanet 351; Galactosialidosis; . PharmGKB PA33572; -; . eggNOG KOG1282; Eukaryota; . eggNOG COG2939; LUCA; . GeneTree ENSGT00860000133774; -; . HOVERGEN HBG053652; -; . InParanoid P10619; -; . KO K13289; -; . PhylomeDB P10619; -; . TreeFam TF323769; -; . BRENDA 3.4.16.5; 2681; . Reactome R-HSA-1660662; Glycosphingolipid metabolism; . Reactome R-HSA-2132295; MHC class II antigen presentation; . Reactome R-HSA-4085001; Sialic acid metabolism; . Reactome R-HSA-6798695; Neutrophil degranulation; . SABIO-RK P10619; -; . SignaLink P10619; -; . ChiTaRS CTSA; human; . EvolutionaryTrace P10619; -; . GeneWiki Cathepsin_A; -; . GenomeRNAi 5476; -; . PRO PR:P10619; -; . Proteomes UP000005640; Chromosome 20; . Bgee ENSG00000064601; -; . CleanEx HS_CTSA; -; . ExpressionAtlas P10619; baseline and differential; . Genevisible P10619; HS; . GO GO:0035578; C:azurophil granule lumen; TAS:Reactome; . GO GO:0005783; C:endoplasmic reticulum; TAS:ProtInc; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; TAS:Reactome; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0043202; C:lysosomal lumen; TAS:Reactome; . GO GO:0005764; C:lysosome; NAS:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0004180; F:carboxypeptidase activity; TAS:ProtInc; . GO GO:0008047; F:enzyme activator activity; TAS:ProtInc; . GO GO:0004308; F:exo-alpha-sialidase activity; TAS:Reactome; . GO GO:0004185; F:serine-type carboxypeptidase activity; IMP:ParkinsonsUK-UCL; . GO GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome; . GO GO:0006886; P:intracellular protein transport; TAS:ProtInc; . GO GO:1904715; P:negative regulation of chaperone-mediated autophagy; IGI:ParkinsonsUK-UCL; . GO GO:0043312; P:neutrophil degranulation; TAS:Reactome; . GO GO:0006508; P:proteolysis; IDA:ParkinsonsUK-UCL; . GO GO:0051603; P:proteolysis involved in cellular protein catabolic process; IBA:GO_Central; . GO GO:1904714; P:regulation of chaperone-mediated autophagy; TAS:ParkinsonsUK-UCL; . GO GO:0031647; P:regulation of protein stability; IMP:ParkinsonsUK-UCL; . Gene3D 3.40.50.1820; -; 1; . InterPro IPR029058; AB_hydrolase; . InterPro IPR001563; Peptidase_S10; . InterPro IPR033124; Ser_caboxypep_his_AS; . InterPro IPR018202; Ser_caboxypep_ser_AS; . PANTHER PTHR11802; PTHR11802; 1; . Pfam PF00450; Peptidase_S10; 1; . PRINTS PR00724; CRBOXYPTASEC; . SUPFAM SSF53474; SSF53474; 1; . PROSITE PS00560; CARBOXYPEPT_SER_HIS; 1; . PROSITE PS00131; CARBOXYPEPT_SER_SER; 1; .

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